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Rotigotine (b)
CAS No. 92206-54-7
Rotigotine (b)( 1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]- )
Catalog No. M24970 CAS No. 92206-54-7
Rotigotine is an antiparkinson agent and dopamine receptor agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 43 | In Stock |
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| 10MG | 63 | In Stock |
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| 25MG | 102 | In Stock |
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| 50MG | 150 | In Stock |
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| 100MG | 223 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRotigotine (b)
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NoteResearch use only, not for human use.
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Brief DescriptionRotigotine is an antiparkinson agent and dopamine receptor agonist.
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DescriptionRotigotine is an antiparkinson agent and dopamine receptor agonist.
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In VitroRotigotine has a 10-fold selectivity for D3 (pKi=9.2) receptors compared with D2, D4 and D5 (pKi=8.5-8.0) and a 100-fold selectivity compared with D1 receptors (pKi=7.2). In functional studies, Rotigotine behaves as full agonist at all dopamine receptors but notably the potency for stimulation of D1 receptors is similar to that for D2 and D3 receptors (pEC50?respectively: 9.0, 9.4-8.6, 9.7).Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone.
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In Vivo——
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Synonyms1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorDopamine
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Research Area——
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Indication——
Chemical Information
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CAS Number92206-54-7
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Formula Weight315.47
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Molecular FormulaC19H25NOS
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCN(CCc1cccs1)C(CC1)Cc2c1c(O)ccc2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chen F , Jin L , Nie Z . Safety and Efficacy of Rotigotine for Treating Parkinson's Disease: A Meta-Analysis of Randomised Controlled Trials[J]. Journal of Pharmacy & Pharmaceutical Sciences, 2017, 20:285-.
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